Hepatitis A virus

Canonical Genome View

Click on feature graphics or labels to view ortholog groups.

Hepatitis A virus image 2B (Unknown function). Click to view ortholog group. VP1. Click to view ortholog group. VP2. Click to view ortholog group. VP3. Click to view ortholog group. VP4a (alt.). Click to view ortholog group. Morphogenesis protein. Click to view ortholog group. Polyprotein a (alt). Click to view ortholog group. Pre-VPg. Click to view ortholog group. Protease. Click to view ortholog group. RNA polymerase. Click to view ortholog group. RNA synthesis protein. Click to view ortholog group. VPg. Click to view ortholog group.

Recent Hepatitis A virus Articles

2009 Jun
[DNA sequence analysis indicates human origin of rotavirus and hepatitis A virus strains from western Colombia]
Moreno et al
Biomedica : revista del Instituto Nacional de Salud
2010 Jan 27
Factors for Predicting Positive Results for Anti-HAV IgM Retesting Among Initially Seronegative Patients.
Shin et al
Digestive diseases and sciences
2010
Detection of enteric viruses in sewage sludge and treated wastewater effluent.
Schlindwein et al
Water science and technology : a journal of the International Association on Water Pollution Research
2010 Jan 22
Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina.
Sasbón et al
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
2010 Jan 25
Comparison of different concentration methods for the detection of hepatitis A virus and calicivirus from bottled natural mineral waters.
Di et al
Journal of virological methods
Organism Photo

Image

Hepatitis A Virus Particles (Virus). Courtesy of Dr.Yuri Khudyakov, Center for Disease Control (CDC)

Pathogen and Disease

Human hepatitis A virus (HAV) belongs to the family Picornaviridae and is the unique member of the genus Hepatovirus. HAV is a major cause of acute hepatitis (AH) worldwide that sometimes leads to fulminant hepatic (FH) failure, evolving in most countries on an endemo-epidemic mode. However, in some countries, notably in Europe, hygienic improvement led to a fall in HAV seroprevalence during last decades exposing populations to a risk of HAV outbreaks.

Viral Classification

Only one serotype of HAV has been identified and a single infection confers lifelong immunity. However, genetic heterogeneity between HAV isolates from different parts of the world has enabled the classification of HAV strains into seven different genotypes, designated I to VII. Four of these have been associated with human disease, I, II, III, and VII. Most human HAV strains belong to genotypes I and III, with 80% of them being genotype I..

For references and expanded Hepatitis A information, please refer to the full PathInfo document.

Orthologs

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